Organ Assist Organ Assist


Please find a selection of relevant publications below. The article summaries can be downloaded via Pubmed.


Machine perfusion of human donor livers with a focus on the biliary tree
A Matton, University of Groningen, 2019 [Download*]

Studies on bile duct Injury and the protective role of oxygenated machine perfusion in liver transplantation
N Karimian, University of Groningen, 2017 [Download*]

Strategies to Improve Outcome after Transplantation of Extended Criteria Donor Livers
AC Westerkamp, University of Groningen, 2016 [Download*]

Bile duct injury in liver transplantation : studies on etiology and the protective role of machine perfusion
S Op den Dries, University of Groningen, 2013 [Download*]

Organ Preservation and Viability in Kidney and Liver Preservation: Experimental and Clinical Studies
MHJ Maathuis, Rijks Universiteit Groningen, 2008 [Download*]

Improving Liver Preservation: New Strategies in Liver Procurement and Preservation
NA ‘t Hart, Rijks Universiteit Groningen, 2007 [Download*]

The Groningen Hypothermic Liver Perfusion Pump for Improved Preservation in Organ Transplantation
A van der Plaats, Rijks Universiteit Groningen, 2005 [Download*]

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Liver perfusion:

Novel Real-time Prediction of Liver Graft Function During Hypothermic Oxygenated Machine Perfusion Before Liver Transplantation
Dutkowski et al, Ann Surg 2019 Nov; 270(5):783-790. [PubMed]

Hypothermic oxygenated machine perfusion reduces bile duct reperfusion injury after transplantation of donation after circulatory death livers
Van Rijn et al, Liver Transpl 2018 May; 24(5):655-664. [PubMed]

► Observations on the ex situ perfusion of livers for transplantation
Watson et al, Am J Transplant 2018 Feb; 10.1111/ajt.14687. [PubMed]

Hypothermic oxygenated machine perfusion (HOPE) for orthotopic liver transplantation of human liver allografts from extended criteria donors (ECD) in donation after brain death (DBD): a prospective multicentre randomised controlled trial (HOPE ECD-DBD)
Zoltan Czigany et al, BMJ 2017 Okt;7(10):e017558. [PubMed]

Dual Hypothermic Oxygenated Machine Perfusion In Liver Transplants Donated After Circulatory Arrest
Van Rijn et al , British Journal of Surgery 2017 Jun;104(7):907-917. [PubMed]

Transplantation of Declined Liver Allografts Following Normothermic Ex-Situ Evaluation
Mergental et al , Am J transplant 2016 Nov; 16(11):3235-3245. [PubMed]

Controlled Oxygenated Rewarming of Cold Stored Livers Prior to Transplantation: First Clinical Application of a New Concept.
Hoyer et al , Transplantation. 2016 Jan;100(1):147-52. [PubMed]

Preimplant Normothermic Liver Perfusion of a Suboptimal Liver Donated After Circulatory Death.
Watson et al , Am J Transplant. 2016 Jan;16(1):353-7. [PubMed]

First Comparison of Hypothermic Oxygenated PErfusion Versus Static Cold Storage of Human Donation After Cardiac Death Liver Transplants
Dutkowski et al , Ann Surg. 2015 Nov; 262(5):764-70. [PubMed]

Liver Preservation With Machine Perfusion an a Newly Developed Cell-Free Oxygen Carrier Solution Under Subnormothermic Conditions
P Fontes, R Lopez, A van der Plaats, Y Vodovotz, M Minervini, V Scott, K Soltys, S Shiva, S Paranjpe, D Sadowski, D Barclay, R Zamora, D Stolz, A Demetris, G Michalopouos, JW Marsh, Americxan journal of Transplantation 2015 Feb [PubMed]

Protective Mechanisms of End-Ischemic Cold Machine Perfusion in DCD Liver Grafts
A Schlegel, Od Rougemont, R Graf, PA Clavien, P Dutkowski, Journal of Hepatology 2013 Feb [PubMed]

Controlled Oxygenated Rewarming of Cold Stored Liver Grafts by Thermaly Graduated Machine Perfusion Prior to Reperfusion
T Minor, P Efferz, M Fox, J Wohlschlaeger, B Lüer, American Journal of Transplantation 2013 Apr [PubMed]

Ex Vivo Normothermic Machine Perfusion and Viability Testing of Discarded Human Donor Livers
S op den Dries, N Karimian, ME Sutton, AC Westerkamp, MWN Nijsten, ASH Gouw, J Wiersema-Buist, T Lisman, HGD Leuvenink, RJ Porte, American Journal of Transplantation 2013 Mar [PubMed]

Superior Preservation of DCD Livers With Continuous Normothermic Perfusion
C Fondevilla, AJ Hessheimer, MHJ Maathuis, J Munoz, P Taura, D Calatayud, HGD Leuvenink, A Rimola, RJ Ploeg, JC Garcia-Valdecasas, Ann Surg. 2011 Sep; 254: 1-8 [PubMed]

Hypothermic Machine Preservation in Liver Transplantation revisited: Concepts and Criteria in the New Millennium
A van der Plaats, NA ‘t Hart, GJ Verkerke, HGD Leuvenink, RJ Ploeg, G Rakhorst, Ann Biomed Eng. 2004 Apr; 31(4): 623-31 [PubMed]

The Groningen Hypothermic Liver Perfusion Pump: Functional Evaluation of a New Machine Perfusion System
A van der Plaats, MHJ Maathuis, NA ‘t Hart, AA Bellekom, HS Hofker, EB van der Houwen, GJ Verkerke, HGD Leuvenink, P Verdonck, RJ Ploeg, G Rakhorst, Ann Biomed Eng. 2006 Dec; 34(12): 1924-34 [PubMed]

Oxygenation during Hypothermic Rat Liver Preservation: An in-vitro slice study to demonstrate beneficial or toxic oxygenation effects
NA ‘t Hart, A van der Plaats, A Faber, P Olinga, HGD Leuvenink, GJ Verkerke, G Rakhorst, RJ Ploeg, , Liver Transplantation 2005 Nov; 11(11): 1403-11 [PubMed]

Determination of an adequate Perfusion Pressure for Continuous Hypothermic Machine Perfusion of the Rat Liver
NA ‘t Hart, A van der Plaats, HGD Leuvenink, H van Goor, J Wiersema-Buist, GJ Verkerke, G Rakhorst, RJ Ploeg, , Transplant Int 2007; 20: 343-52 [PubMed]

Hypothermic Machine Perfusion of the Liver and the Critical Balance between Perfusion Pressures and Endothelial Injury
NA ‘t Hart, A van der Plaats, HGD Leuvenink, H van Goor, GJ Verkerke, G Rakhorst, RJ Ploeg, , Transplant Proceedings 2005; 37: 332-334 [PubMed]


  Kidney perfusion:

Oxygenated Kidney Preservation Techniques
SA Hosgood, HF Nicholson, ML Nicholson; 93(5): 455-9, Transplantation 2012 Mar [PubMed]

Improved Kidney Graft Function after Preservation using a Novel Hypothermic Machine Perfusion Device
MHJ Maathuis, S Manekeller, A van der Plaats, HGD Leuvenink, NA ‘t Hart, AB Lier, G Rakhorst, RJ Ploeg, T Minor, Ann Surg. 2007 Dec; 246(6): 982-991 [PubMed]


  Lung perfusion:
In Situ Lung Perfusion is a Valuable Tool to Assess lungs from Donation After Circulatory Death Donors Category I-II
C van de Wauwer, AJ Munneke, GE Engels, FM Berga, G Rakhorst, MW Nijsten, MA Mariani, ME Erasmus, Transplant International 2013 May [PubMed]