Organ Assist Organ Assist

Technology

The proprietary technology behind all our devices is mainly the same. All our perfusion machines consist of at least one (or more) pump unit(s), for most devices a Thermo unit and a work bench/trolley. The main difference is that every device is designed for a specific organ type, because of our extensive experience of 10 years clinical application we know that every organ needs dedicated treatment.

Oxygen: the game changer!

The most important feature of all our devices is that they allow for true oxygenated perfusion. Multiple (clinical) research projects have already proven that the addition of oxygen to the perfusion fluid has positive effects on the organ(s) as well as the transplant results. Livers for transplant for example show that just hypothermic oxygenated perfusion is improving graft quality and survival and prevents for ischemic cholangiopathy after transplant. The same applies to kidney grafts: active oxygenation is improving results with regards to rejection rates and eGFR. And of course the capability of active oxygenation is also very important when you switch from hypothermic to normothermic perfusion; a capability of most of our machines as well.

Organ specific settings: pressure controlled

Every system has dedicated preset perfusion pressures, which are depending on the perfusion temperature and the type of organ. These presets can be changed during setup and perfusion, but will also be limited to the actual perfusion temperature to be able to maintain safety of the graft during the procedure on the machine.

Proven pump design: true pulsatile flow

The proven pump design allows for true pulsatile flow, independent of the perfusion pressure. Pulsatile perfusion has benefits for the arterial circulation and micro circulation of the grafts. The venous inflow of an organ will of course be provided with a continuous flow patern in that way that we provide the vessel what is is used to.

Common user interface: easy to learn and implement

The user interface of our devices is the same for every device, which makes it easy to implement and extend our technology in your department. Not too many buttons that might confuse the user, but straight forward controls to allow every trained user to setup and control the machine at every moment and in every situation. Without the hassle of browsing through instructions every time to prepare and use the machine(s). Everything aimed to be user friendly and safe.

Industry unique: adjustable perfusion temperature

The Thermo unit gives you the choice of setting your prefered temperature environment for the organ. This provides you an industry unique opportunity of perfusing in between hypothermic and normothermic temperatures. You can even choose to slowly warm (or cool) the organ(s) during the procedure. A unique feature no other commercial available device can offer for your organs for transplant. We understand that different types of organ categories that have benefit of a different treatment. We offer the platform that is capable of doing it all.

 

Clinical Trials

The following clinical trials are ongoing using Organ Assist technology:

Kidney

COPE:

  • POMP trial: oxygenated hypothermic kidney re-conditioning after cold storage (inclusion finished)
  • COMPARE trial: oxygenated vs. non oxygenated hypothermic machine perfusion in kidney transplantation. (UPDATE April 2017: inclusion finished!)

Liver